The Outcome Of Patients With "Nodal" Peripheral T-Cell Lymphomas In A Complete Response Following Standard Chemotherapy.

8555 Background: The outcome of peripheral T-cell lymphomas (PTCLs) treated with anthracycline-based chemotherapy (CHT) regimens is poor. Previous studies have suggested a benefit of high dose chemotherapy and autologous stem cell transplant (HDC/ASCT) in first complete remission (CR). However, in the absence of a randomized trial, the benefit is unclear. We evaluated the outcome of patients in CR following CHOP (like) CHT to provide a comparison to outcomes with HDC/ASCT. Methods: The BCCA Lymphoid Cancer database was searched to identify all cases of ‘nodal’ PTCLs between 16 and 67 y with stage 3/4, or stage 1/2 with B symptoms, bulky (u003e10cm) or extensive disease, that were in a CR by clinical assessment and imaging at the end of curative intent combination CHT and did not undergo consolidative transplant. Charts were reviewed to confirm response assessment. Results: Between October 1980 and January 2014, 103 cases were identified to be in a CR (6 by PET scan): PTCL-NOS = 39/94 (45%); ALK-positive (ALK-...