Pharmacokinetic and pharmacogenetic analysis in patients with advanced nasopharyngeal carcinoma (NPC) treated with 5-flurouracil (5-FU) and cisplatin
Journal of Clinical Oncology, 2017.
6063 Background: Many studies have demonstrated several pharmacokinetic and pharmacogenetic factors may affect the efficacy and toxicity of 5-FU. These factors include system drug exposure (area under the concentration-time curve, AUC), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD). This study is to investigate corre...More
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