Second Malignancies In Patients With Neuroblastoma: A Report From The International Neuroblastoma Risk Group Project.

10019 Background: Exposures to radiation and chemotherapy are associated with increased risk of second malignant neoplasms (SMN) in neuroblastoma survivors. However, it remains unclear if modifications in risk-based treatment strategies during the past 25 years have changed SMN rates. Methods: The International Neuroblastoma Risk Group (INRG) Task Force created a database of neuroblastoma patients diagnosed from 1974-2013. SMN risk was measured by cumulative incidence, standardized incidence ratios (SIR) and absolute excess risk (AER) per 10,000 person-years relative to a matched United States population. Poisson regression compared rates of SMN between different groups. Results: Of the 16,520 patients in the INRG database, 9,261 enrolled on Children’s Oncology Group protocols had SMN data available. 79 (0.85%) patients developed SMN, including hematologic malignancies (n = 38), sarcomas (n = 19), carcinomas (n = 10), CNS tumors (n = 10), hepatoblastoma (n = 1), and nephroblastoma (n = 1). The incidence o...