Effect Of Very Small Tumor Size On Recurrence-Free Survival And Breast Cancer-Specific Mortality Stratified By Guideline Adherence: An Analysis Of The Brenda Study Group

1096 Background: Small tumor size (u003c5mm, T1a) carry an excellent prognosis, despite a variety of treatment approaches. Controversy exists over the extent of treatment, as to whether less than conventional treatment can be done. We therefore sought to explore the effect of very small tumor size on RFS and BCSM stratified by guideline adherence. Methods: The multicenter study population included 8935 early breast cancer patients diagnosed between 1992-2008, where 614 patients (6.9%) were T1a. T1a-patients were categorized according to guideline adherence and the influence on survival was calculated by Cox proportional hazard analyses (adjusted for age, grading, nodal status, hormonal status and co-existing morbidity). Results: The median age was 61 years and the median follow-up was 55 months. 449 [73.1%] patients were postmenopausal. 13.1% had G1, 61.9% G2 and 25% G3. 81.9% were HR positive and 18.4% HER2/neu-positive. 77.1% were N0, 11.9% had 1-3 and 11% more than 3 affected lymph nodes. Only 262 (42.7%) ...