Toxicity And Survival In Older Versus Younger Esophageal Cancer (Ec) Patients (Pts) Treated With Neoadjuvant Chemoradiotherapy (Ncrt).

204Background: Trimodality therapy (TMT) for EC is associated with significant toxicity. Limited data are available on the safety of nCRT in vulnerable populations such as older pts. We evaluated the associations between age and toxicity as well as survival in pts treated with nCRT as part of TMT. Methods: A retrospective review of pts with EC treated with nCRT as part of TMT at an academic cancer center between 2002-2014 was conducted. We assessed the impact of age (u003c65 versus ≥65) on chemotherapy dose reduction/interruption (DRI), hospitalizations (H), and toxicity including grade 3/4 (G3+T), and composite number of any grade non-hematologic (NHT) or hematologic (HT) toxicity. Relapse free (RFS) and overall survival (OS) were assessed with the Kaplan-Meier (KM) method. Univariate (UVA) and multivariate regression analyses (MVA) were performed. Results: 125 pts were identified. The median age was 63 (range 35-80) with 46% of patients ≥65.There were increased co-morbidities in older pts and more active sm...