A Meta-Analysis Of Randomized Clinical Trials In Acute Promyelocytic Leukemia (Apl).

7040 Background: All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) have dramatically improved treatment outcomes in Acute Promyelocytic Leukemia (APL). To address the question regarding the most effective and safe regimen for 1st--line APL, a meta-analysis was performed following a systematic review of the clinical literature in APL. Methods: A systematic literature review on all published randomized controlled trials (RCT) in APL identified 17 papers. One additional publication was included following discussions with a clinical expert. Comparable RCTs were grouped into networks based on similar induction and consolidation regimens, resulting in three networks for meta-analysis. Network 1 consisted of RCTs with ATRA, anthracycline (AraC), and chemotherapy (Chemo) regimens. Three trials with arsenic + ATRA arms made up Network 2; observation maintenance arms from 3 studies commprised Network 3. Results: In Network 1, ATRA + AraC + Chemo + ATO was associated with superior event-free survival (EFS) a...