A Nomogram To Individually Predict The Presence Of Chemotherapy-Induced Nausea And Vomiting (Cinv) In Cancer Patients

e20680 Background: Chemotherapy-induced nausea and vomiting (CINV) remains one common side effect of cancer treatment, whose presence depends on multiple factors. Prophylactic management of CINV is far more important than the rescue therapy after it happens. Here, we aimed to build a model-based nomogram to predict the individual probability of CINV, which is crucial to guide treatment decisions regarding the use of antiemetic. Methods: Patients from eight clinical trials of antiemetic agents in China from 1985 to 2013 were used to screen eligible subjects, who should have received highly, moderately, or lowly emetogenic chemotherapy (HEC/MEC/LEC) and be evaluable for the outcome of CINV. Complete response during overall phase (0~120 hours after chemotherapy) was used to assess the efficacy of antiemetics. Information on demographics, performance status (PS), alcohol use, motion sickness, history of pregnancy vomiting (PV), antiemetic regimen and other potential risk factors of CINV were examined. Multiva...