Multicolor Genetically Encoded Calcium Sensitive Bioluminescent Reporters of Neural Activity for Brain Machine Interfaces

Mitchell A. Pender,Karen Lin, Amanda Bares,Michael G. Kaplitt,Chris B. Schaffer,Nozomi Nishimura

Brain（2017）

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摘要

Adeno-associated virus was used to express a mix of different colored, aequorin-fluorescent proteins in mouse cortex. Neural activity produced bioluminescence with spectral properties that changed with different stimulation.

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