Concentrations of circulating adiponectin and adipocyte-fatty acid binding protein in patients with three-vessel coronary artery disease: a comparison with coronary lesion complexity as characterized by syntax score

Objective: In this study, we investigated the correlation between coronary lesion complexity as characterized by syntax score (SS) with circulating adiponectin and adipocyte-fatty acid binding protein (A-FABP4) concentrations in the presence of stable coronary artery disease affecting three coronary vessels (three-vessel stable CAD). Methods: The study groups consisted of 41 control subjects (28 males and 13 females, non-CAD group) and 115 affected subjects (79 males and 36 females, three-vessel stable CAD group). We divided into tertiles the three-vessel stable CAD group according to SS and estimated circulating concentrations of adiponectin and A-FABP4. Results: We did not find any correlation between the coronary lesion complexity with either the adiponectin and/or A-FABP4. We found lower the A-FABP4 of the non-CAD group than those of the groups with three-vessel stable CAD (p < 0.001). Adiponectin were lower in DM subjects (p < 0.05 for each group); though A-FABP4 were found to be higher (p < 0.05 for each group) according to non-DM subjects in intra-group comparisons. Conclusion: Adiponectin is not a suitable parameter for demonstrating the existence of CAD or predicting coronary lesion complexity. A-FABP4 is more useful for the proof of the presence of CAD but A-FABP4 are not correlated with the severity of CAD.