Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors

Guoqiang Dong,Yuxin Fang,Yang Liu,Na Liu,Shanchao Wu,Wannian Zhang,Chunquan Sheng

Bioorganic & Medicinal Chemistry Letters（2017）

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摘要

A series of non-camptothecin topoisomerase I (Top1) inhibitors were designed and synthesized. Compound 8s showed good Top1 inhibitory activity and potent in vitro antitumor activity.

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关键词

Topoisomerase I inhibitors,Anthrathiadiazole,Antiproliferative activity,Structure-activity relationship

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