Decision Analysis Of Contralateral Prophylactic Mastectomy For Women With Sporadic, Unilateral, Early-Stage Breast Cancer.

e12572 Title: Decision analysis of contralateral prophylactic mastectomy for women with sporadic, unilateral, early-stage breast cancer Background: An increasing number of women with sporadic, unilateral, early-stage breast cancers are choosing to undergo contralateral prophylactic mastectomy (CPM). The aim of this study was to compare overall survival outcomes between CPM and no CPM with continued surveillance following treatment of a primary breast cancer to assist clinical decision-making. Methods: We created an individual-based, state-transition Markov model. We considered women treated for sporadic stage I, II, or III, estrogen receptor (ER) positive and ER-negative breast cancer at ages 40, 50, 60, and 70. To simulate overall survival outcomes for breast cancer patients, we implement an initial 10-year risk period for the development of contralateral breast cancer (CBC) and mortality from the primary or CBC following treatment for the primary and CBC. We incorporated adjustments for mortality probab...