Immunogenicity and safety of a quadrivalent inactivated influenza vaccine compared with two trivalent inactivated influenza vaccines containing alternate B strains in adults: A phase 3, randomized noninferiority study
Vaccine(2017)
摘要
•Seqirus IIV4 was compared to two IIV3 comparators with alternate B lineage strains.•Seqirus IIV4 was immunologically noninferior to both IIV3 comparators.•The immunogenicity of IIV4 was superior for the IIV3 unmatched B strain.•IIV4 was well tolerated, with a similar safety profile to IIV3 comparators.
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关键词
Immunogenicity,Inactivated,Influenza vaccine,Noninferiority,Quadrivalent,Safety
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