ATORVASTATIN ACTIVE METABOLITE INHIBITS OXIDATION OF APOB-CONTAINING LIPOPROTEIN PARTICLES OF DIFFERENT SIZES MEASURED IN VITRO UNDER HYPERGLYCEMIC CONDITIONS

R. Preston Mason,Samuel C.R. Sherratt,Robert F. Jacob

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2017）

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摘要

Background: Atorvastatin has been shown to reduce cardiovascular events in diabetic patients of diverse ethnicity through cholesterol-lowering as well as cholesterol-independent pathways. The pleiotropic benefits associated with atorvastatin may be related to the reduced oxidation of apoB-containing

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关键词

atorvastatin,lipoprotein particles,hyperglycemic conditions,metabolite,oxidation,apob-containing

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