HOMOCYSTEINE ACCELERATED THE DISORDER OF LIPID METABOLISM VIA REGULATING PCSK9 AND LXRA-ABCA1/ABCG1 PATHWAY
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2017）
摘要
Background: Homocysteine is an independent risk factor of atheroslceorsis, characterized by the formation of macrophage-derived foam cells. Liver X receptor alpha (LXRα) can keep cholesterol homeostasis, while proprotein convertase subtilisin/kexin 9(PCSK9), a lipid metabolism regulatory protein
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