Enantioselective rhodium-catalyzed hydroacylation to access the four stereoisomers of anti-rodent difenacoum

Maïwenn Jacolot,Sylvie Moebs-Sanchez,Florence Popowycz

Tetrahedron Letters（2017）

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摘要

•The first enantioselective synthesis of the four stereoisomers of difenacoum.•The key step was an asymmetric hydroacylation reaction.•The 4 stereoisomers were obtained with ee≈96% and de >96%.

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关键词

Asymmetric catalysis,4-Hydroxycoumarin,Hydroacylation,Chiral HPLC

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