Selection of aptamers to Neisseria meningitidis and Streptococcus pneumoniae surface specific proteins and affinity assay using thin film AlN resonators

•SOMAmers selection against surface specific protein PavA from Streptococcus pneumoniae.•SOMAmers selection against surface specific protein FHbp from Neisseria meningitidis.•Fabrication of bulk acoustic wave-solidly mounted resonator based on AlN tilted for in liquid measuring.•Functionalization method based on APTES that binds protein strongly to the surface and avoids non-specific binding.•High sensitivity detection of SOMAmer binding to meningitis specific proteins in real time.