Altered blood oxidative stress biomarkers in association with canine pyoderma and allergic contact dermatitis

Skin diseases are a common problem in dogs that may lead to increased risk of oxidative stress. This work was designed to estimate selected oxidative stress markers (superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and plasma zinc) in pyoderma- and allergic contact dermatitis (ACD)-affected dogs. This study was carried out on 25 dogs, in which ten dogs were used as controls, nine dogs were affected with pyoderma, and six dogs had ACD. Analysis of oxidative stress markers showed a significant decrease of the mean values of GPx and CAT enzymes in pyoderma-infected dogs while showing a significant increase of the mean value of SOD enzymes along with a decrease of the plasma zinc level in ACD-affected dogs. Pyoderma and ACD are associated with significant changes in plasma biomarkers of oxidative stress.