Targeting BACE 1(Beta secretase) through Polyphenolic compounds -A computational insilico approach with emphasis on binding site analysis

Polyphenolic compounds posses vast number of biological activities and they are the inclusions of phytoconstituents of plant kingdom. Synthetic drugs used in the treatment of neurodegenerative disorders like Alzheimer’s disease is of only symptomatic and for not permanent cure over the progression of the disease. Beta secretase- 1(BACE1) is aspartic protease makes improper cleavage of amyloid precursor protein (APP) found on the membrane of the neuronal cells and produces the accumulation of beta amyloid proteins of insoluble fractions. Polyphenolic compounds like catechin3gallate, hesperidin, hesperitin etc., were found to possess lowest binding energy with best conformation, when comparing with the standard reference ligands. In this insilico docking studies, it revealed that targeting BACE1 inhibition, through Polyphenolic compounds can create number of lead molecules for better therapeutic concern in future.