Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC

Nathaniel C. Holcomb, Mamta Goswami,Sung Gu Han,Timothy L. Scott,John A. D’Orazio,David K. Orren,C. Gary Gairola,Isabel Mellon

DNA Repair（2017）

引用 24|浏览11

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摘要

•Arsenic delays removal of UV-induced photolesions.•Arsenic reduces XPC protein expression.•Arsenic reduces XPC, XPA, and DDB2 RNA expression.•Arsenic-mediated XPC protein inhibition is proteasome dependent.

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关键词

Arsenic,UV light,Nucleotide excision repair,XPC,Skin cancer,Lung cancer

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