Survival after Salvage Total Laryngectomy: The Influence of Previous Treatment

Purpose: To compare the complications and survival rate after different treatment modalities of advancedlaryngopharyngeal cancer.Methods: Retrospective study included 619 advanced laryngopharyngeal carcinoma, treated with either primary total laryngectomy (PTL), or salvage (STL) after laryngectomy, radio, chemoradiotherapy. Complications andsurvival rate were documented.Results: Five years disease free survival rate amounted 60.9% for PTL, 54.3% for STL after partial laryngectomy, 50% for STL after radiotherapy and 43.8% for STL after chemoradiotherapy. Histologically positiveneck was highly significantly associated with worse prognosis, much more than recurrence within larynx.Conclusion: PTL gives the best survival rate with low complications for advanced laryngopharyngeal squamous cell carcinoma. Complications and survival rate of STL significantly depend on previous treatment oflaryngopharyngeal cancer.