CPEB4 links the clock and the UPR to protect the liver
NATURE CELL BIOLOGY（2017）
摘要
Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.
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关键词
Circadian rhythms,Endoplasmic reticulum,Metabolism,Translation,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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