Pharmacogenetics of antidepressant response: A polygenic approach

•Antidepressant efficacy, major depressive disorder and schizophrenia are complex polygenic traits.•Genetic overlap has been previously demonstrated among different psychiatric disorders.•Polygenic risk scores did not predict antidepressant efficacy between two independent samples.•Polygenic risk scores did not show overlap between antidepressant efficacy and major depressive disorder.•Polygenic risk scores did not show overlap between antidepressant efficacy and schizophrenia.