Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study

Jean Lacau St Guily,Alexandra Rousseau,Bertrand Baujat,Sophie Périé,Philippe Schultz,Béatrix Barry,Xavier Dufour,Olivier Malard,Jean-Luc Pretet,Christine Clavel,Philippe Birembaut,Silvia Franceschi

Oral Oncology（2017）

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摘要

•27% oropharyngeal cancer patients (France) were HPV+; many were also smokers.•HPV+ patients had 2-fold better progression-free survival (PFS) than HPV-negative.•Only lack of upfront surgery had an equally strong effect on PFS as HPV.•Lack of upfront surgery was especially detrimental in HPV-negative patients.•Poorer PFS in HPV-negative may derive from more genomic damage or bulkier tumours.

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关键词

Oropharyngeal cancer,Human papillomavirus,Tobacco,Surgical treatment,Progression-free survival,Survival

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