Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival

M. Chen,Z. Xue,X. Zhang,J. Xu,L. Wu,Y. Ma

Cellular Immunology（2017）

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摘要

•SOCS1 genetic modification efficiently confers low expression of MHC and costimulatory molecules on mDCs.•DC-SOCS1 induce T-cell hypo-responsiveness in vitro.•DC-SOCS1 pretreated recipients had prolonged islet allograft survival in vivo.

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关键词

Dendritic cell,Immune tolerance,Islet transplant,SOCS1,T-cell hypo-responsiveness

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