Unrelated Cord Blood Transplantation After Nonmyeloablative Conditioning: Single Institutional Retrospective Comparison With Bone Marrow Or Peripheral Blood Stem-Cell Transplants

Background: Unrelated cord blood transplantation (CBT) has emerged as an effective therapy for treating patients with advanced or high-risk hematologic diseases who have no suitable related or unrelated donor. In older patients or those with extensive prior therapy or other clinical features, nonmyeloablative regimens have been used to reduce the risk of regimen-related toxicity and transplantation-related mortality (TRM). Several studies have been reported on the use of unrelated CBT using various reduced-intensity conditioning regimens.