MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion
Nature（2017）
摘要
Crystal structures of engineered human MFN1 in different stages of GTP hydrolysis provide insights into the GTP-induced conformational changes that promote MFN1 dimerization to bring about mitochondrial fusion.
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关键词
Membrane structure and assembly,Mitochondria,X-ray crystallography,Science,Humanities and Social Sciences,multidisciplinary
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