Targeting sonic hedgehog signaling in neurological disorders

Sita Sharan Patel,Sunil Tomar,Diksha Sharma,Neeraj Mahindroo,Malairaman Udayabanu

Neuroscience & Biobehavioral Reviews（2017）

引用 59|浏览20

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摘要

•Sonic hedgehog (Shh) signaling plays a major role in neurogenesis.•Shh activate Smo via Ptch receptor to induce Gli1 transcription.•Small molecules reviewed targeting Shh signaling.•Dysregulation of Shh signaling in brain induces neurological disorders.

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关键词

Neurogenesis,Neurological disorders,Small molecules,Sonic hedgehog

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