Role of leptin in conditioned place preference to high-fat diet in leptin-deficient ob/ob mice

Yoshiyuki Shimizu,Cheol Son,Daisuke Aotani,Hidenari Nomura,Takatoshi Hikida,Kiminori Hosoda,Kazuwa Nakao

Neuroscience Letters（2017）

引用 25|浏览4

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摘要

•Conditioned place preference for a high fat diet was examined among ob/ob mice.•Higher place preference for a high fat diet was shown in ob/ob mice.•Leptin treatment decreased the preference in ob/ob mice independently of obesity.•Leptin suppresses food intake by inhibiting the hedonic feeding pathway.

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关键词

Leptin,Reward system,Conditioned place preference,ob/ob mouse

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