Lessons from contemporary trials of cardiovascular prevention and rehabilitation: A systematic review and meta-analysis

•Most prevention and rehabilitation programmes do not longer reduce mortality.•Comprehensive prevention and rehabilitation programmes managing six or more risk factors continue to be effective in reducing all-cause mortality.•Programmes that integrate prescription of cardioprotective medication also continue to reduce all-cause mortality.•Myocardial infarction and, for the first time, cerebrovascular events are reduced.