Leptin, inflammatory biomarkers and body composition in patients with sarcoidosis

Leptin is a hormone secreted by adipocytes, with a variety of physiological activities including control of metabolism,energy homeostasis,neuroendocrine regulation,activation of the immune system. Aim: the aim of the study was to explore possible relationships between serum concentration of leptin and selected proinflammatory cytokines in patients with sarcoidosis(pts). Methods: 40 pts(22M 18F) mean age 45y±11.5y, were enrolled in to the study. Mean time of observation was 5.6±5.0y. Blood samples were collected in the morning and stored at -80°C until assayed. Serum leptin(sL), tumour necrosis factor(TNF-α), interleukin(IL)-1s,5,6 and C-reactive protein(CRP) were quantified. Bioelectrical impedance was used to measure fat-free mass(FFM),fat mass(FM) using a Bodystat 1500 and the FFMI(fat-free mass index) was defined. Results: on average male subjects showed lower level of sL (7.03±5.07 ng/ml) compared with females (28.7±38.5ng/ml) which is explained by the different distribution of adipose tissue. Statistically significant correlation (p Conclusions: our findings could support the role of CRP as a biomarker among sarcoid patients but does not support correlation between sL and TNF-α, IL-5 and 6 in the studied group. All these findings need to be verified with large-scale studies.