The cause of cancer mutations: Improvable bad life or inevitable stochastic replication errors?
Molecular Biology(2016)
摘要
Despite substantial progress in understanding the mechanisms of carcinogenesis and fighting oncology diseases, cancer mortality remains rather high. Therefore, there is a striving to reduce this mortality to the level determined by endogenous biological factors. The review analyzes the mutations that lead to cell malignant transformation and describes the contribution that self-renewal of adult tissues makes to tumorigenesis. Cancer progression is considered as a development of a complicated system where cells mutate, evolve, and are subject to selection. Cancer paradoxes are described in conclusion.
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关键词
mutation, cancer, tumor evolution, driver genes, self-renewal
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