Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.

Leticia Serrano-Oviedo,José M. Giménez-Bachs,Syongh Y. Nam-Cha,Francisco J. Cimas,Jesús García-Cano,Ricardo Sánchez-Prieto,Antonio S. Salinas-Sánchez

Urologic Oncology: Seminars and Original Investigations（2017）

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摘要

•Analysis of the status of various proteins related to VHL gene is proposed.•Relation of these proteins with clinical factors explains the molecular behavior.•ERK5 may be a new prognostic marker in renal cancer.

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关键词

Clear cell renal cell carcinoma,VHL,Signaling pathway,Biomarkers

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