Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia

Toni Grönroos,Susanna Teppo,Juha Mehtonen,Saara Laukkanen,Thomas Liuksiala,Matti Nykter,Merja Heinäniemi,Olli Lohi

Leukemia Research（2017）

引用 5|浏览15

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摘要

•PTP4A3 is overexpressed in specific subtypes of acute lymphoblastic leukemia.•ETV6-RUNX1 and BCR-ABL1 subtypes show strongest expression of PTP4A3.•MLL-rearranged leukemias exhibit low level of PTP4A3 expression.•PTP4A3 is regulated by the ETV6-RUNX1 fusion.•Inhibition or knockdown of PTP4A3 has no marked effect on leukemia cell viability.

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关键词

E/R,pre-B-ALL,PTP4A,PRL,AML,CML,shRNA,GRO-seq

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