Friend or foe?: The tumour microenvironment dilemma in colorectal cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer(2017)
摘要
The network of bidirectional homotypic and heterotypic interactions established among parenchymal tumour cells and surrounding mesenchymal stromal cells generates the tumour microenvironment (TME). These intricate crosstalks elicit both beneficial and adverse effects on tumour initiation and progression unbalancing the signals and responses from the neighbouring cells.
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关键词
Colorectal cancer,Tumour microenvironment,Stromal cells,Cancer-associated fibroblasts,Immune cells,Cell-cell communications
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