Synthesis, structure and properties of N-aminosaccharin - A selective inhibitor of human carbonic anhydrase I

Mikhail A. Kuznetsov,Aleksandr N. Shestakov,Mikhail Zibinsky,Mikhail Krasavin,Claudiu T. Supuran,Stanislav Kalinin,Muhammet Tanc

Tetrahedron Letters（2017）

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摘要

•Previously unknown N-aminosaccharin was prepared.•N-Aminosaccharin activity in different reactions has been investigated.•N-Aminosaccharin was identified to be a selective low micromolar inhibitor of hCA I.

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关键词

N-Aminosaccharin,N-Amination,hCA I inhibitor,Oxidative aminoaziridination,Ligand efficiency

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