Impact of detergents on the physiochemical behavior of itraconazole loaded nanostructured lipid carriers

A. Bhadra,Gourab Karmakar,Prasant Nahak,Priyam Chettri,Biplab Roy,Pritam Guha,Amit Kumar Mandal,Ranendu Kumar Nath,Amiya Kumar Panda

Colloids and Surfaces A: Physicochemical and Engineering Aspects（2017）

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摘要

•NLCs were prepared with triolein, cetyl palmitate and palmitic acid.•Cationic, anionic, zwitterionic and nonionic surfactants were used as stabilizers.•Antifungal drug, itraconazole was loaded into NLC.•Physicochemical characterizations of drug loaded NLCs were done.•Drug loaded NLCs showed superior antifungul activities.

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关键词

NLC,ITZ,DLS,DSC,Drug release,Antifungul activity

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