Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats

Jing Chen,Jing Zhang,Jian Yang,Lin Xu,Qi Hu,Changwu Xu,Shuo Yang,Hong Jiang

Atherosclerosis（2017）

引用 38|浏览6

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摘要

•Histone demethylase KDM3a, a novel regulator of vascular smooth muscle cells, controls vascular neointimal hyperplasia in diabetic rats.•KDM3a and H3M9me2 were involved in metabolic memory after vascular injury in diabetic condition.•KDM3a expression is closely associated with the development of neointimal hyperplasia in diabetes.•KDM3a might function as a key regulator of vascular remodeling in diabetes via Rho/ROCK and AngII/AGTR1 signaling pathways.

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关键词

KDM3a,H3K9 methylation,Vascular smooth muscle cell,Diabetes mellitus

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