Co-Transplantation Haploidentical Mesenchymal Stem Cells And Hematoietic Stem Cells With Nonmyeloablative Condition For Treatment Of Relapsed Or Refractory Acute Leukaemia.

Background The major problems of haploidentical stem cell transplantation is severe graft versus host disease (GVHD) and graft rejection because of MHC barrier. Recently, some studies shown that mesenchymal stem cells (MSCs) which can be differentiat into various cells of MSCs origin has some good ability of immunosuppressive activity which may be used for enhance hematopoietic engraftment and lessen GVHD after transplant. So we desinged the protocole of co-transplantation haploiddentical MSCs and perpheral blood stem cell with nonmyeloablative conditions based on our past clinical trails of NST with HLA-march donor and haploid transplant experiment of Rhesus and want to improve the effective of haploidentical transplant in relapsed or refractory acute leukaemia