Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNAs to bystander cells

B-cell chronic lymphocytic leukemia (CLL) is characterized by the clonal accumulation of mature apoptosis-resistant tumor cells in lymphoid tissues and the peripheral blood. Recently genetic and epigenetic aberrations associated with the pathogenesis, the progression, and the response to therapy