Antibacterial profiling of abietane-type diterpenoids

Andreas Helfenstein,Mikko Vahermo,Dorota A. Nawrot,Fatih Demirci,Gökalp İşcan,Sara Krogerus,Jari Yli-Kauhaluoma,Vânia M. Moreira,Päivi Tammela

Bioorganic & Medicinal Chemistry（2017）

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摘要

•Novel derivatives of abietic and dehydroabietic acid were synthesized.•Biological activity was evaluated against a panel of bacteria and fungi.•Compound 10 is active against certain Gram-positive bacteria, including MRSA.

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关键词

Abietic acid,Dehydroabietic acid,Amino acid derivative,Bacteria,Fungi,Cytotoxicity

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