Pet-Based Textural Analysis Assessment In Early Stage Hodgkin Lymphoma Treated With Standard Combined Approach

BACKGROUND Interim 18F-fluorodeoxyglucose positron tomography (PET) has been shown to be a prognostic factor for clinical outcome in Hodgkin lymphoma (HL). Predicting an early cancer9s response to chemotherapy could enhance clinical care management by enabling the personalization of treatment plans based on predicted outcome. Tumour texture can be measured from medical images that provide a non-invasive method of capturing intratumoral heterogeneity and hence could potentially allow a prior assessment of a patient9s predicted response to treatment. PURPOSE The aim of the study was to assess the applicability of the pre-treatment PET-based textural analysis (TA) in a cohort of early stage HL and its correlation with early response to chemotherapy. METHODS We reviewed medical records of patients with early stage HL diagnosed between January 2012 and December 2014 treated with standard combined modality therapy. All PET scans were reviewed by a local nuclear medicine physician, blinded for the clinical outcome and interim PET (iPET) results. TA was applied to pre-treatment PET images in order to extract features which can be used as prognostic factors for early treatment response. TA features provide unique information about the spatial variation of pixels in the segmented Volume of Interests (VOIs) where it is applied thus they are able to quantitatively score tumor heterogeneity. In order to do this, two different strategies were employed. First was to segment pathological lymph nodes with a 40% of SUVmax isocontour algorithm. Each lymphnode was analysed with TA as a stand-alone in order to increase the number of observations. Second strategy was to extract two cubes of 3 and 4 cm3 of volume from the highest metabolically active mediastinic region. Seventy-four textural features were calculated mathematically and then analyzed with statistical non parametric test (Kruskall Wallis test). Features which showed prognostic power (or patient stratification ability) were employed to build Receiver Operating Curve (ROC) in order to score their sensibility and specificity. RESULTS Twenty-four patients were selected. After iPET revision, 17 patients were considered disease free after 2 cycles of ABVD whereas the remaining 7 patients had a positive iPET. Considering each lymph node as a stand-alone we were able to analyse 84 cases.The Kruskall Wallis test showed that 5 out of 74 TA features could separate iPET responders and non-responders patients with statistical significance (p CONCLUSION Textural biomarkers as an intratumoral heterogeneity quantification tool hold great promise for the early prediction of tumor outcomes. In this work, we demonstrated the applicability of the PET-based TA in a cohort of cases with early HL. This method requires further validation in a larger prospective study. Disclosures No relevant conflicts of interest to declare.