Cytokine Patterns Of Patients With Hcv/Hbv Co-Infection

showed marked differences between the DM group and non-DM group. Patients with longer duration of CHB (≥15 years) and alcoholic steatosis showed the highest likelihood of T2DM (OR = 5.39 and 4.95; 95% CI 2.76–10.53 and 1.65–14.91). In the multivariate adjusted analysis, three CHB-related factors, namely high viral load, long duration of illness, and presence of cirrhosis, contributed to substantially increase the likelihood of T2DM, together with other five risk factors including family history of DM, low education level, elevated gamma-glutamyl transferase (GGT), triglycerides (TG) levels, and presence of alcoholic steatosis. CONCLUSIONS: High viral load, long duration of CHB, presence of cirrhosis, alcoholic steatosis and several other factors may be potential risk factors for development of T2DM in CHB patients. It is recommended to monitor glucose in high-risk CHB patients and aggressively intervene on modifiable risk factors.