Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
Felix R. Day,Deborah Thompson,Hannes Helgason,Daniel I. Chasman,Hilary Finucane,Patrick Sulem,Katherine S. Ruth,Sean Whalen,Abhishek Sarkar,Eva Albrecht,Elisabeth Altmaier,Marzyeh Amini,Caterina Barbieri,Thibaud Boutin,Archie Campbell,Ellen W. Demerath,Ayush Giri,Chunyan He,Jouke J. Hottenga,Robert Karlsson,Ivana Kolcic,Po-Ru Loh,Kathryn L. Lunetta,Massimo Mangino,Brumat Marco, Gerorge McMahon,Sarah E. Medland,Ilja M. Nolte,Raymond Noordam,Teresa Nutile,Lavinia Paternoster,Natalia Perjakova,Eleonora Porcu,Lynda Rose,Katharina E. Schraut,Ayellet V. Segrè,Albert V. Smith,Lisette Stolk,Alexander Teumer,Irene L. Andrulis,Stefania Bandinelli,Matthias W. Beckmann,Javier Benitez,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Stig E. Bojesen,Manjeet K. Bolla,Judith S. Brand,Hiltrud Braunch,Hermann Brenner,Linda Broer,Thomas Brüning,Julie E. Buring,Harry Campbell,Eulalia Catamo,Stephen J. Chanock,Georgia Chenevix-Trench,Tanguy Corre,Fergus J. Couch,Diana L. Cousminer,Angela Cox,Laura Crisponi,Kamila Czene,George Davey-Smith,Eco J. C. de Geus,Renne de Mutsert,Immaculata De Vivo,Joe Dennis,Peter Devilee,Isabel dos-Santos-Silva,Alison M. Dunning,Johan G. Eriksson,Peter A. Fasching,Lindsay Fernández-Rhodes,Luigi Ferrucci,Dieter Flesch-Janys,Lude Franke,Marike Gabrielson,Ilaria Gandin,Graham G. Giles,Harald Grallert,Daniel F. Gudbjartsson,Pascal Guénel,Per Hall,Emily Hallberg,Ute Hamann,Tamara B. Harris,Catharina A. Hartman,Gerardo Heiss,Maartje J. Hooning,John L. Hopper,Frank B. Hu,David J. Hunter,Arfan Ikram,Hae Kyung Im,Marjo-Riitta Järvelin,Peter K. Joshi,David Karasik,Zoltán Kutalik,Genevieve Lachance,Diether Lambrechts,Claudia Langenberg,Lenore J. Launer,Joop S.E. Laven,Stefania Lenarduzzi,Jingmei Li,Penelope A. Lind,Sara Lindström,Yongmei Liu,Jian'an Luan,Reedik Mägi,Arto Mannermaa,Hamdi Mbarek,Mark McCarthy,Christa Meisinger,Thomas Meitinger,Cristina Menni,Andres Metspalu,Kyriaki Michailidou,Lili Milani,Roger L. Milne,Grant W. Montgomery,Anna Marie Mulligan,Michael A. Nalls,Pau Navarro,Heli Nevanlinna,Dale R. Nyholt,Albertine J. Oldehinkel,Tracy O'Mara,Sandosh Padmanabhan,Aarno Palotie,Nancy L. Pedersen,Annette Peters,Julian Peto,Paul Pharoah,Anneli Pouta,Paolo Radice,Iffat Rahman,Susan M. Ring,Antonietta Robino,Frits R. Rosendaal,Igor Rudan,Rico Rueedi,Daniela Ruggiero,Cinzia Sala,Marjanka K. Schmidt,Robert A. Scott,Mitul Shah,Rossella Sorice,Melissa C. Southey,Ulla Sovio,Meir J. Stampfer,Maristella Steri,Konstantin Strauch,Toshiko Tanaka,Emmi Tikkanen,Nicholas J. Timpson,Michela Traglia,Thérèse Truong,Jonathan Tyrer,André G. Uitterlinden,Digna R. Velez Edwards,Veronique Vitart,Uwe Völker,Peter Vollenweider,Qin Wang,Elisabeth Widen,Ko Willems van Dijk,Gonneke Willemsen,Robert Winqvist,Bruce H. R. Wolffenbuttel,Jing Hua Zhao,Magdalena Zoledziewska,Marek Zygmunt,Behrooz Z. Alizadeh, Dorret I. Boomsma,Marina Ciullo,Francesco Cucca,Tonu Esko,Nora Franceschini,Christian Gieger,Vilmundur Gudnason,Caroline Hayward,Peter Kraft,Debbie A. Lawlor,Patrik K. E. Magnusson,Nicholas G. Martin,Dennis O. Mook-Kanamori,Ellen Aagaard Nohr,Ozren Polasek,David J. Porteous,Alkes L. Price,Paul M. Ridker,Harold Snieder,Tim D. Spector,Doris Stöckl,Daniela Toniolo,Sheila Ulivi,Jenny A. Visser,Henry Völzke, Nicholas J. Wareham, James F. Wilson, kConFab,Aocs Investigators,Amanda B. Spurdle,Unnur Thorsteinsdottir,Katherine Pollard,Douglas F. Easton,Joyce Tung,Jenny Chang-Claude,David Hinds,Anna Murray,Joanne M. Murabito,Kari Stefansson,Ken K. Ong,John Perry
bioRxiv（2016）
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摘要
The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Here, we analyse 1000-Genome reference panel imputed genotype data on up to ~370,000 women and identify 389 independent signals (all P
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关键词
puberty timing,cancer susceptibility,genomic analyses,menarche,bmi-independent
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