The challenges of modulating the 'rest and digest' system: acetylcholine receptors as drug targets.
Drug Discovery Today(2017)
摘要
•The acetylcholine system has a major role in the autonomic nervous system.•Acetylcholine receptors are targets for many clinically approved drugs.•Receptor subtype specificity can influence which downstream effects are modulated.•Levels of regulation tune the acetylcholine system to existing biologic conditions.•This intricate regulation must be taken into consideration in ligand design.
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