Comparing the measured basal metabolic rates in patients with chronic disorders of consciousness to the estimated basal metabolic rate calculated from common predictive equations

Summary Background Accurately predicting the basal metabolic rate (BMR) of patients in a vegetative state (VS) or minimally conscious state (MCS) is critical to proper nutritional therapy, but commonly used equations have not been shown to be accurate. Therefore, we compared the BMR measured by indirect calorimetry (IC) to BMR values estimated using common predictive equations in VS and MCS patients. Methods Body composition variables were measured using the bioelectric impedance analysis (BIA) technique. BMR was measured by IC in 82 patients (64 men and 18 women) with VS or MCS. Patients were classified by body mass index as underweight ( 2 , n = 34) or normal-weight (18.5 ≤ BMI  2 , n = 48). BMR was estimated for each group using the Harris–Benedict (H–B), Schofield, or Cunningham equations and compared to the measured BMR using Bland–Altman analyses. Results For the underweight group, there was a significant difference between the measured BMR values and the estimated BMR values calculated using the H–B, Schofield, and Cunningham equations (p  Conclusions None of the commonly used equations to estimate BMR were suitable for the VS or MCS populations. Indirect calorimetry is the preferred way to avoid either over or underestimate of BMR values.