G + C content differs in conserved and variable amino acid residues of flaviviruses and other evolutionary groups
Infection, Genetics and Evolution(2016)
摘要
Flaviviruses are small RNA viruses that exhibit genetic and ecological diversity and a wide range of G+C content (GC%). We discovered that, amongst flaviviruses, the GC% of nucleotides encoding conserved amino acid (AA) residues was consistently higher than that of nucleotides encoding variable AAs. This intriguing phenomenon was also identified for a wide range of other viruses, and some non-viral evolutionary groups. Here, we analyse the possible mechanisms underlying this imbalanced nucleotide content (in particular the role of the specific G content and the AA composition in flaviviral genomes) and discuss its evolutionary implications. Our findings suggest that one of the most simple characteristics of the genetic code (i.e., the G or G+C content of codons) is linked with the evolutionary behavior of the corresponding encoded AAs.
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关键词
AA,APOIV,CA-Cons,CA-Var,CDS,CXFV,DENV,GC%,ISFV,JEV,MBFV,MODV,MMLV,NKV,ORF,PW,RBV,TBEV,TBFV,WNV,YFV
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