Phosphorylation regulates activity of 7-dehydrocholesterol reductase (DHCR7), a terminal enzyme of cholesterol synthesis

Anika V. Prabhu,Winnie Luu,Laura J. Sharpe,Andrew J. Brown

The Journal of Steroid Biochemistry and Molecular Biology（2017）

引用 29|浏览5

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摘要

•Inhibition of AMPK or PKA decreases DHCR7 activity.•Mutation of S14 in DHCR7 decreases activity independently of AMPK and PKA.•In the skin, phosphorylation of DHCR7 may divert flux from cholesterol to vitamin D synthesis.

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关键词

7DHC,AMPK,CaMKII,CHO,CKI,DHCR7,HMGCR,PBGD,PKA,SLOS

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