The role of the KRSIK motif of human angiogenin in heparin and DNA binding

The positively charged surface with a (KRSIK54)-K-50 motif is the main interaction site of hAng for both heparin and DNA binding, providing an insight into the potential role of the (KRSIK54)-K-50 motif for the internalization and promoter binding of hAng, which is essential for the regulation of angiogenesis.