Mansoins C-F, Oligomeric Flavonoid Glucosides Isolated From Mansoa Hirsuta Fruits With Potential Anti-Inflammatory Activity
JOURNAL OF NATURAL PRODUCTS(2016)
摘要
Continued investigation of the polyphenolic pool of the fruits of Mansoa hirsuta afforded four additional members of the new class of glucosylated oligomeric flavonoids comprising a flavanone core linked to 1,3-diarylpropane C-6-C-3-C-6 units. The structures and absolute configurations of mansoins C-F (3-6) were established by analysis of NMR and electronic circular dichroism data. Mansoin C (3) was identified as a diglucosylated heterodimer, whereas mansoins D (4), E (5), and F (6) were identified as triglucosylated heterotrimers, isomeric with mansoin A (1). Mansoin F (6) inhibited TNF-alpha release by lipopolysaccharide-stimulated THP-1 cells (IC50 of 19.3 +/- 1.3 mu M) and, as with mansoin A (1), reduced the phosphorylation levels of p-65-NF-kappa B, when assayed at 50 mu M. These results indicate that the potential anti-inflammatory properties of mansoin F (6) are probably due to inhibition of the NF-kappa B pathway and inhibition of TNF-alpha release.
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