Study on the inclusion behaviour and solid inclusion complex of lomustine with cyclodextrins

The water soluble solid inclusion complex of three native or modified cyclodextrins (CDs) including β -cyclodextrin ( β -CD), hydroxypropyl- β -cyclodextrin (Hp- β -CD) and 2,6-di- o -methyl- β -cyclodextrin (DIME- β -CD) and Lomustine (CCNU) were presented with the orthogonal experiment investigation of the reaction conditions. The inclusion behaviors were comparatively investigated by nuclear magnetic resonance in combination with infrared spectroscopy, thermogravimetric analysis, X-ray diffractometry and scanning electron microphotographs. The experimental results jointly demonstrated that the entrance of CCNU into the cavity of the CDs by intermolecular forces as well as hydrophobic forces and resulting in the significantly improvement of the thermostability of CCNU. Graphical Abstract